Celiac disease is diagnosed in three steps:

• Clinical doubt
• Serologic test
• Bioptic test

Clinical doubt is the first step; it’s the moment a doctor considers the patient’s symptoms as a sign of celiac disease or considers them in a risk category.

For feedback on this doubt, serologic dosing is done for: Antigliadin antibodies (AGA), Anti- endosmosis Antibodies (EMA), Anti- tissue transglutaminase antibodies (tTG).

If the person is positive to these antibodies, they then go on to do biopsies of the small intestine, removing a piece of tissue to check the state of the intestinal villis.

Celiac disease is only definitely diagnosed if the bioptic test is positive.